A Multiscale Model of the Neonatal Circulatory System Following Hybrid Norwood Palliation

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Conventional treatment of Hypoplastic Left Heart Syndrome (HLHS), the Norwood operation, establishes univentricular circulation through a series of highly invasive reconstructive procedures. The relatively new Hybrid Norwood operation involves a less invasive strategy that
avoids a cardiopulmonary bypass (heart-lung machine), deliberate cardiac arrest, and circulatory arrest of the patient in the neonatal period. The resulting circulation after this procedure is complex and detailed hemodynamics have yet to be fully understood. To this end, a multiscale model of the entire circulatory system was developed utilizing an electrical lumped parameter model (LPM) for the peripheral or distal circulation coupled with a 3D Computational Fluid Dynamics (CFD) model to understand the local hemodynamics.

This study was supported in part by the Orlando Health Foundation and by the American Heart Association under Grant number 11GRNT7940011.

Author Company: 
University of Central Florida
Author Name: 
Andres Ceballos