Using CFD to Increase Yields in Fermentation Production Methods
Thursday, March 3, 2016

The pharmaceutical and chemical process industries face many challenges, such as the rising costs of raw material and the need to develop processes and innovative products that meet safety regulation and performance demands.

Fermentation is a widely used biotechnology to produce bio-products such as alcohols, pharmaceutical compounds, alternative fuels or feedstocks for the chemical and other industries. The process itself is driven by microorganisms which are highly sensitive to the conditions in the reactor, like temperature, pH-value, oxygen and substrate concentration or shear rate. As the complexity of these operations continues to increase, poor scale-up designs lead to incrementally lower production yields, higher material costs, and a reduced bottom line.

Computational Fluid Dynamics (CFD) and particle modeling with Discrete Element Method (DEM) have been identified as key enabling technologies in finding solutions to many of the challenges that surround scale-up, as they are capable of reducing operating costs across manufacturing and quality divisions.

Of specific interest is gas-liquid mixing. This is the focal point of this webcast. We present several case studies, a demonstration on G-L CFD simulation for mixing, effective use of mesh type and bubble size distribution.

Ravindra Aglave
Thomas Eppinger
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